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Danhong injection in the treatment efficacy of ischemic stroke


Key words ischemic stroke; Danhong injection; efficacy evaluation; Xiangdan injection 【Abstract】 Objective To explore the clinical curative effect of Danhong injection intreating ischemic cerebral stroke. Methods 198 cases of ischemic cerebral stroke were randomly dividedinto the treatment group (99cases) and the contrast group (99cases). The treatment group was treated by danhong injection (30 ml) with mainline one time each day. The contrast group was treated by xiangdaninjection (20 ml) with mainline one time each day. The clinical curative effect, traum a score of nerve function and change of hemorheology were observed between the two groups. Results The parameter of hemorheology and trauma of nerve function were obviously improved (P <0.01). The total effectrate and improvement of hemorheology in the treatment group has a significant difference compared with those in the contrast group (P <0.01). Conclusion Danhong injection can improve the parameter of hemorheology and trauma of nerve function of ischemic cerebral stroke obviously. Danhong injection was proved to be effective intreatingischemic cerebral stroke, and it is superior to xiangdan injection in curative efficacy. 【Key words】 Ischemic cerebral stroke; Danhong injection; Curative effect evaluation; Xiangdan injection of cerebrovascular high incidence of disease in recent years, the incidence of ischemic stroke in an upward trend [1], and therefore the treatment of ischemic stroke and more attention. Improve the efficacy of ischemic stroke,[link widoczny dla zalogowanych], reduce morbidity and mortality in clinical research. In this paper,[link widoczny dla zalogowanych], observed Danhong injection on the clinical efficacy of ischemic stroke, blood parameters and neurological deficit score, and to explore its role in the treatment of ischemic stroke. 1 Materials and Methods 1.1 General Information All the cases were hospital from December 2005 to December 2007 inpatient and outpatient patients,[link widoczny dla zalogowanych], selected cases were found in 1995 the fourth brain Disease Conference adopted the \First onset cases were randomly divided into treatment and control groups: treatment group 99 patients, 78 males and 21 females, aged 35 to 80 years, mean (68 ± years; brain under the 1995 Fourth National Disease Conference neurological deficit by scoring rate [3], neurological deficit score (20. 8 ± 6.3) points. The control group 99 cases, 77 males and 22 females, aged 36 to 82 years, mean (69 ± 1) years of age. Neurological deficit score (19.9 ± 8.7) points. 2 groups of gender, age, neurological deficit score showed no significant (P> 0.05), comparable. 1.2 treatment groups were based on underlying disease, as appropriate, to give blood pressure, blood sugar, dehydration, anti-platelet aggregation and neurotrophic and other conventional treatment. Conventional therapy in the treatment group on the basis of the above given Danhong injection 30 ml 5% glucose solution or 250 ml of normal saline intravenously, 1 / d; control group added with 20 ml Xiangdan intravenous injection , 1 / d; were treated for 14 d. 1.3 evaluation standard reference to the standard [3]. Two groups of patients were hospitalized, the treatment for 14 days neurological function. According to changes in neurological deficit scores and the effect of disability to determine the level of classification. Basic recovery: Functional impairment score decreased 91% to 100% degree of disability grade 0; significant progress: impairment score reduction of 46% to 90% degree of disability from 1 to 3; progress: impairment score decreased by 18% ~ 45%; No change: functional impairment score decreased <17%. 1.4 Laboratory tests of both groups were measured before and after treatment urine routine, liver and kidney function, blood rheology, coagulation analysis, and electrocardiogram. 1.5 statistical methods of measurement data as mean ± standard deviation (x ± s) said, using a paired t test. Count data using χ 2 test; application SPSS11.0, software for statistical analysis. 2 results 2.1 2 clinical efficacy, the difference was significant (P <0.01). 2.2 points the two groups were compared neurological deficit after treatment than before treatment integral significantly improved; points after treatment, compared with the control group, the difference was statistically significant (P <0.01). 2.3 2 blood rheology before and after treatment 2 group of patients before treatment changes in whole blood low shear, high shear viscosity and plasma viscosity, erythrocyte deformation index was significantly higher than normal,[link widoczny dla zalogowanych], 2 groups before and after treatment and the treatment group compared with the control group were statistically significant. Table 3. 3 discussions the highest mortality of stroke is now one of the three diseases, especially in ischemic stroke is most common in China residents accounted for 60% to 70%. Ischemic stroke with high mortality, high morbidity and high medical expenses and other characteristics, it is a heavy burden on society and the family. Reduce mortality and morbidity of the disease is the key to active acute rescue treatment, the main way: ① thrombolytic, anti-platelet aggregation, cerebral blood flow restoration; ② nerve cells and endothelial cell protection therapy, to prevent the ischemia and reperfusion of brain tissue caused by a series of pathological and biochemical reactions, reduces disability. Increased blood viscosity and high-coagulation due to thrombosis occurred in ischemic cerebrovascular disease a major cause of lower blood viscosity in ischemic stroke will undoubtedly become an important target for clinical treatment. Ischemic stroke is a medicine, \Stagnation is the context, the brain awakened,[link widoczny dla zalogowanych], caused by blood barrier, the blood line of poor, the key is to treat blood circulation. Stasis to the new blood of Health, organs and meridians to nutrition, to restore limb function.
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