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mbt scarpe outlet Adefovir dipivoxil and entecavir

 
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PostWysłany: Pon 6:31, 13 Gru 2010    Temat postu: mbt scarpe outlet Adefovir dipivoxil and entecavir

Adefovir dipivoxil and entecavir treatment in patients with active cirrhosis Clinical efficacy of 48 weeks


Key words Chronic hepatitis B; active cirrhosis; adefovir dipivoxil; entecavir � � 【Abstract】 Objective To evaluate the efficacy and safety of 48 weeks adefovir dipivoxil (ADV ), endecavir treatment for patients with active cirrhosis. Methods 60 patients with active cirrhosis were randomly dividedinto two groups. An adefovir dipivoxil (ADV) group: 30 patients treated with 10 mg of ADV a day; and an endecavir (ETV) group: 30 patiens treated with 0.5mg of ETV a day. The course of treatment lasted 48 weeks. Serum levels of alanine amino transferase (ALT), aspartate amino transferase (AST), ALB, TBiL, HBeAg, HBV DNA, PCIII, IVC, LN,[link widoczny dla zalogowanych], and HA, renal function and drug adverse reactions during the treatment of the two groups were checked , compared and analyzed. Result The ratios of recovery for fiver functions and the negativity rate of HBV DNA, HBeAg, included sero-conversion rate of HBeAg / HBeAb, were increased with prolongation of the treatment period; However the differences between the two groups were not significant. Two groups were not suffered from virus variation. No drug related renal function impairment was found during the treatment. Two patients of each group had adverse drug reactions but both were mild. ConclusionThe efficacy and safety of adefovir dipivoxil and endecavir treatment for the above patients were similar, but the ratio of negativity rate of HBV DNA is lower in the ETV treatment group. � 】 【Key words Chronie Hepatitis B; Active liver cirrhosis; Adefovk dipivoxil; Endecavir � cirrhosis of the liver caused by chronic hepatitis B, the continuing inflammatory activity is active cirrhosis, or hepatitis sclerosis, cirrhosis of the liver and more active replication of the virus associated with infection, inflammation and necrosis of varying severity,[link widoczny dla zalogowanych], the treatment of the weight of antiviral treatment, the drugs mainly nucleoside analogues, the author with adefovir dipivoxil and entecavir for active hepatitis B patients with cirrhosis do comparative observation of antiretroviral therapy, will now report the results as follows. Materials and Methods � 1 � 1.1 Case Selection Qingdao City Hospital for Infectious Diseases August 2006 to June 2007 were treated with cirrhosis (active) 60 patients, 40 cases of male and female 20 patients, aged 30 to 62 years, mean 45.2 years old, diagnosis of viral hepatitis prevention and treatment programs in 2000 diagnostic criteria [1]. In which 42 patients with decompensated liver cirrhosis, 18 patients with decompensated. All patients positive for serum HBeAg and HBV DNA (patients with decompensated requirements HBV DNA> 105 copies / ml, ALT greater than 1ULN). Adefovir dipivoxil were randomly divided into 30 patients, 21 males and 9 females, aged 30 to 59 years,[link widoczny dla zalogowanych], mean 43.1 years, of which 21 cases compensated, decompensated 9 cases, 7 cases with ascites (moderate), within six months there have been 2 cases of spontaneous bacterial peritonitis, gastrointestinal bleeding in 4 cases, 1 case of hepatic encephalopathy. Entecavir group of 30 patients, 19 males and 11 females, aged 30 to 62 years, mean 46.9 years, of which 21 cases compensated, decompensated 9 cases, 6 cases with ascites (moderate), six months Spontaneous bacterial peritonitis occurred in 4 cases, gastrointestinal bleeding in 5 cases, 2 cases of hepatic encephalopathy. The incidence of complications in the two groups were compared, the difference was not statistically significant. Patients had hepatorenal syndrome, the exclusion of other causes of liver disease, 12 months, did not receive immunomodulatory agents or anti-viral treatment. � 1.2 treatment of all patients were given conventional liver protection and support, symptomatic treatment for 2 to 8 weeks, then adefovir dipivoxil to adefovir dipivoxil group (Tianjin Institute of Pharmaceutical Research Pharmaceutical limited liability company ) l0 mg / d, orally; entecavir group to entecavir (Bristol-Myers Squibb U.S. production) 0.5 mg / d, orally, applied for 48 weeks. � 1.3 OUTCOME MEASURES ALT, AST, ALB,[link widoczny dla zalogowanych], TBiL, HBeAg,[link widoczny dla zalogowanych], HBV DNA, Ⅲ procollagen (PC Ⅲ), IV collagen (Ⅳ A C), laminin (LN), hyaluronic acid ( HA). Review every 4 weeks 1 liver function, review each week 1 l2 HBeAg, HBV DNA, liver fibrosis markers, renal function. Adverse drug reactions were also observed. � 1.4 detection method for the detection of liver and kidney function in Japan Olympus automatic biochemical analyzer and related reagents. HBV DNA detection by fluorescence quantitative PCR method, kit purchased from Bio Co., Ltd. Shenzhen, the base piece. Liver fibrosis markers test kits purchased from the United Biotechnology Co., Ltd. Hai Beixi, even by enzyme immunosorbent assay. HBeAg detection by enzyme-linked immunosorbent assay. Operate in strict accordance with the instructions by hand. �
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