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 Wysłany: Czw 12:35, 10 Lut 2011 Temat postu: ghd glätteisen Recombinant hepatitis B vaccine imm |
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Recombinant hepatitis B vaccine immune effect gene
9 (2001) 06--641--01 recombinant gene in order to understand the immune effect of hepatitis B vaccine in September t1999 to March 2001 at the Shandong University students was observed. l objects and to observe the object as Shandong University, 99 852 students, aged 17 ~ 2l years of age, serum hepatitis B surface antigen (HBsAg) negative, alanine aminotransferase (ALT) normal, not previously injected with hepatitis B vaccine. Using simple random sampling method to observe the subjects were divided into vaccinated group and control group,[link widoczny dla zalogowanych], matching the ratio of l: l, the two groups in gender, age, living and learning environment, are comparable. September 1999 on the inoculated by routine immunization 0,1,6 months, Beijing Institute of Biological Products inoculation of recombinant yeast producing hepatitis B gene vaccine (lot number 99062-18, valid 2001.04), inoculation doses were 5Fg. 1 year after completion of full vaccination, measured by enzyme immunoassay of hepatitis B virus infection in five indicators, reagents from the sea on the research�� Biotechnology Industry Branch of China Ltd, the use of valid, according to manual operation and determine the results. 2 Results 1 year after inoculation,[link widoczny dla zalogowanych], inoculated HBsAg,[link widoczny dla zalogowanych], HBeAg negative; control group, HBsAg,[link widoczny dla zalogowanych], HBeAg-positive rates were 3.29 and 2.58, higher than the control group were inoculated group, the difference was statistically significant (. = 14.23,366.2, P 0.05). Table 1. Hepatitis B vaccine throughout the atlas lZ 1 year after vaccination Serum hepatitis B virus markers Ao 3 to discuss the test results reported in the literature,[link widoczny dla zalogowanych], gene recombinant hepatitis B vaccine has a good safety, immunogenicity and reliable protective effect, the protection rate is generally 75 or more ]. With the results. Peng Junying et al study shows that genetically engineered hepatitis B vaccine in a routine anti-HBs positive after vaccination rate up to 95.85], significantly lower compared with the results. Analysis of weeks may be due to its original object of this observation is only detected before vaccination HBsAg and ALT, not detection of hepatitis B virus infection and other indexes. In addition, vaccination of a group of anti HBc, anti-HBe positive rate of a control group, no significant difference, indicating an obvious observation of the object status of HBV infection. HBV infection and the immune response to vaccination was significantly lower than non-HBV infection (Peng Junying study HBV infection before inoculation 5 indexes all negative), therefore, the best detection of HBV infection before inoculation of the 5 indexes, HBsAg, HBeAg, anti- HBc as a positive observation of the object is not to rule out other factors, the effect of the vaccine. 4
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