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人多药耐药基因—1及二氢叶酸还原酶基因共转导小鼠造？… lood,belstaff italia，1994；84：1408—1414CotransductionofHumanmdr·1andDihydrofolateReductaseGenesintoMurineHematopoieticCellsLIUXiaodanYUXiaodanGUoZikuanLIXiusenLIUYuanlinMAONing(InstituteofBasicMedicalSciencesB~ing100850)AbstractTransferofdrugresistancegeneslntohematopoieticcellsiSanattractiveapproachtoprotecthematopoieticsystemfromthetoxiceffectsbychemotherapeuticagentsincancerpatientsInthisstudy,tory burch reva，transductionofmdr一1incombinationwithdihydrofolatereductase(dhfr)genewasperformed，andtheexpressionofexogenousgenesandchemoprotectioncapacityinmousebonemarrowcellswereobservedTheresultsshowedthatapproximately15％ofbone1T~rlx3Wcellstransfectedwiththeretroviralvectorexpressedmdr1asassayedbyflowcytomelry．Genetramsferresultedinabout09—13foldand0．5—26foldincreaseintheresistanceofCFU_GMtotaxolandmethotrexateinvitro，respectively(P<005)Moreover．sevenmonthsaftertransplantationtosyngeneicmicewithmdr-1anddhfr-transfeetedbonemarrowcells．peripheraibloodcellsinrecipientswerestillpositivef0rgpl70asevaluatedbyFAcsaswellasformdr一1anddhfrbyPcRamplification．Theseresultsindicatethathematopoieticprogenitorscanbetransfectedbyretroviruscontainingmdr一1anddhfrgenes,ugg stiefel，andthatfunctionaldrugresistanceaccompaniestheirexpressions．Furthermore，geneticchimerlsmmightexistinhematopoieticstemcells．Inconclusion,p90x workout schedule，transferandexpressionofmdr一1anddhfrgenesinbonemarrowcellsmightbeappli—cableingenetherapyresearchincancerpatients．Keywordsdrugresistancegenemultidrugresistancegene一1dihydrofolatereductasegenegenecotransductionhematopoieticcells More articles related to topics： tory burch sale 尖锐湿疣患者治疗前后血清IL-2、IL-6 uggs bestellen 慢性肾脏病骨代谢及其疾病的临床实践 spyder jackets outlet 重组人白细胞介素11对卡铂致猕 |
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